Ajax will be without youngsters Ahmetcan Kaplan, Devyne Rensch and Mohamed Ihattaren due to injuries, while midfielder Kenneth Taylor is doubtful due to a muscle strain.
Despite bagging a brace in his side's 4-1 victory away to RKC Waalwijk at the weekend, Brian Brobbey is likely to make way for Mohammed Kudus in attack, with the Ghana forward potentially full of confidence after scoring a superb equaliser at Anfield last month.
Liverpool, meanwhile, will travel without Diaz, Jota and Joel Matip due to injuries, but they could welcome back Nunez, Thiago Alcantara and Ibrahima Konate to their matchday squad.
Nunez and Thiago will almost certainly come into the starting XI should they be deemed available, while Konate may replace Joe Gomez alongside Virgil van Dijk depending on the assessment of his recent strain.
Alex Oxlade-Chamberlain and Naby Keita have both resumed training after long-term muscle injuries, but neither were included in the Reds' Champions League squad as the midfield duo were not expected to be ready in time to make a significant contribution at the group stage.
Ajax possible starting lineup:
Pasveer; Sanchez, Timber, Bassey, Blind; Klaassen, Alvarez, Berghuis; Tadic, Kudus, Bergwijn
Liverpool possible starting lineup:
Alisson; Alexander-Arnold, Konate, Van Dijk, Robertson; Henderson, Thiago; Elliott, Firmino, Nunez; Salah